The core components of Changchangqing do not consist of a single chemical monomer, but rather form a composite bioactive system built upon the theory of ubiquitin-mediated protein degradation. This system primarily comprises high-concentration probiotic metabolites, specific functional probiotic strains, and prebiotics, with the aim of activating the cellular clearance mechanism through a co-nourishing of humans and gut microbiota approach. Unlike conventional supplements that directly supply exogenous nutrients, Changchangqing's formulation logic is designed to activate the body's own cleanup crew—the ubiquitin-proteasome system. If intracellular abnormal proteins are not cleared in a timely manner, they can cause clogging. By modulating the gutb-in axis and systemic immune-inflammatory responses, the ingredients in Changchangqing indirectly optimize the ubiquitination environment within cells, thereby accelerating the elimination of these garbage proteins.